High‐dose vs low‐dose regimens of thrombolytic agents
30‐Day mortality · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 302 participantsVery low
Findings
What do systematic reviews say?
13 questions · 13 findings · 2 reviews · Vascular
No studies found 2 · 15.4%GRADE not reported 3 · 23.1%Very low 7 · 53.8%Low 1 · 7.7%Moderate 0 · 0%High 0 · 0%
High‐dose vs low‐dose regimens of thrombolytic agents
Vessel patency (at end of treatment) · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 302 participantsVery low
High‐dose vs low‐dose regimens of thrombolytic agents
Duration of thrombolysis (to end of treatment) · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 302 participantsVery low
High‐dose vs low‐dose regimens of thrombolytic agents
Stroke · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 302 participantsVery low
High‐dose vs low‐dose regimens of thrombolytic agents
Major bleeding · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 302 participantsVery low
High‐dose vs low‐dose regimens of thrombolytic agents
30‐Day amputation‐free survival · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 302 participantsVery low
High‐dose vs low‐dose regimens of thrombolytic agents
Amputation · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 302 participantsVery low
ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH
Thrombosis · people with antiphospholipid antibodies and no history of thrombosis
1 finding from 1 review
- Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 120 participantsGRADE not reported
ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH
Bleeding ‐ major/excessive · people with antiphospholipid antibodies and no history of thrombosis
1 finding from 1 review
- Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 120 participantsGRADE not reported
ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH
Subcutaneous bruises · people with antiphospholipid antibodies and no history of thrombosis
ASA + high‐dose LMWH showed no clear difference in subcutaneous bruises compared with ASA + low‐dose LMWH or UFH (low certainty).
1 finding from 1 review
- Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes onlyRR 1 [0.34, 2.93]2 studies · 120 participantsLow
ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH
All‐cause mortality · people with antiphospholipid antibodies and no history of thrombosis
The review found no eligible studies for this question.
1 finding from 1 review
- Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH
Quality of life · people with antiphospholipid antibodies and no history of thrombosis
The review found no eligible studies for this question.
1 finding from 1 review
- Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH
Adverse events other than bleeding · people with antiphospholipid antibodies and no history of thrombosis
1 finding from 1 review
- Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes onlyno estimate extracted1 participantsGRADE not reported