Findings

What do systematic reviews say?

2 questions · 4 findings · 1 reviews · Neonatal

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No studies found 2 · 50%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 0 · 0%High 0 · 0%

High‐dose vs standard‐dose strategies

Side effects (tachycardia, agitation, or feed intolerance) leading to a reduction in dose or withholding of caffeine · preterm infants at risk for apnea

The review found no eligible studies for this question.

1 finding from 1 review

Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High‐dose vs standard‐dose strategies

Side effects (tachycardia, agitation, or feed intolerance) leading to a reduction in dose or withholding of caffeine · preterm infants with or at risk for apnea of prematurity

It is very uncertain whether high‐dose changes side effects (tachycardia, agitation or feed intolerance) leading to… compared with standard‐dose strategies (very low certainty).

3 findings from 1 review

Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity 2023 · Cochrane Headline outcomes only
RR 1.92 [0.53, 6.9]
2 studies · 150 participants
Very low
Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity 2023 · Cochrane Headline outcomes only
RR 1.66 [0.86, 3.23]
5 studies · 593 participants
Low