Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 185 findings · 21 reviews

No studies found 48 · 25.9%GRADE not reported 26 · 14.1%Very low 30 · 16.2%Low 54 · 29.2%Moderate 23 · 12.4%High 4 · 2.2%

High‐dose colchicine vs placebo

Proportion with 50% or greater decrease in inflammation score from baseline ‐ 32 to 36 hours · acute gout

High‐dose colchicine may leads to higher reduction of inflammation: proportion with 50% or greater decrease… compared with placebo (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Total adverse events · acute gout

High‐dose colchicine may leads to higher total adverse events compared with placebo (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

High‐dose colchicine may leads to higher participant global assessment of treatment success: proportion with… compared with placebo (low certainty).

1 finding from 1 review