What do systematic reviews say?

Heparin plus aspirin vs aspirin

Heparin plus aspirin may leads to higher live birth compared with aspirin (low certainty).

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  RR 1.27 [1.09, 1.49]
  5 studies · 1295 participants
  Low

Heparin plus aspirin vs aspirin

Heparin plus aspirin showed no clear difference in pre‐eclampsia compared with aspirin (low certainty).

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  RR 0.57 [0.1, 3.14]
  2 studies · 82 participants
  Low

Heparin plus aspirin vs aspirin

Heparin plus aspirin showed no clear difference in adverse events in the mother ‐ Bleeding compared with aspirin (low certainty).

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  RR 1.65 [0.19, 14.03]
  1 study · 31 participants
  Low

Heparin plus aspirin vs aspirin

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 140 participants
  GRADE not reported

Heparin plus aspirin vs aspirin

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 90 participants
  GRADE not reported

Heparin plus aspirin vs aspirin

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 182 participants
  GRADE not reported

Heparin plus aspirin vs aspirin

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 182 participants
  GRADE not reported

Heparin plus aspirin vs aspirin

Heparin plus aspirin may leads to lower pregnancy loss compared with aspirin (low certainty).

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  RR 0.48 [0.32, 0.71]
  5 studies · 1295 participants
  Low

Heparin plus aspirin vs aspirin

It is very uncertain whether heparin plus aspirin changes preterm delivery of a live infant compared with aspirin (very low certainty).

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  RR 0.93
  3 studies · 156 participants
  Very low

Heparin plus aspirin vs aspirin

It is very uncertain whether heparin plus aspirin changes intrauterine growth restriction compared with aspirin (very low certainty).

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  RR 0.85 [0.33, 2.19]
  3 studies · 151 participants
  Very low

Heparin plus aspirin vs aspirin

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 51 participants
  GRADE not reported