Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 1 reviews · Schizophrenia

No studies found 6 · 31.6%GRADE not reported 0 · 0%Very low 5 · 26.3%Low 7 · 36.8%Moderate 1 · 5.3%High 0 · 0%

HALOPERIDOL vs RISPERIDONE

Repeated need for rapid tranquillisation ‐ needing additional benzodiazepine · patients with psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in repeated need for rapid tranquillisation ‐ needing additional… compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Specific behaviours ‐ agitation >50% reduction in PANSS‐EC score · patients with psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in specific behaviours ‐ agitation >50% reduction in PANSS‐EC score compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Global outcome ‐ rated as severe ‐ CGI‐S · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome ‐ rated as severe ‐ CGI‐S compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Adverse effects: specific ‐ acute dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ acute dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

1 finding from 1 review