Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 25%Moderate 3 · 75%High 0 · 0%

H2 receptor antagonists vs proton pump inhibitors

Blood transfusion · people admitted to intensive care units

H2 receptor antagonists showed no clear difference in number of participants requiring blood transfusion compared with proton pump inhibitors (moderate certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.98 [0.75, 5.21]
3 studies · 575 participants
Moderate

H2 receptor antagonists vs antacids

Blood transfusion · people admitted to intensive care units

H2 receptor antagonists probably leads to higher number of participants requiring blood transfusion compared with antacids (moderate certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 2.49 [1.35, 4.62]
6 studies · 744 participants
Moderate

H2 receptor antagonists vs sucralfate

Blood transfusion · people admitted to intensive care units

H2 receptor antagonists showed no clear difference in number of participants requiring blood transfusion compared with sucralfate (low certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.25 [0.7, 2.23]
9 studies · 1095 participants
Low

H2 receptor antagonists vs placebo or no prophylaxis

Blood transfusion · people admitted to intensive care units

H2 receptor antagonists probably leads to lower number of participants requiring blood transfusions compared with placebo or no prophylaxis (moderate certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 0.58 [0.36, 0.95]
7 studies · 655 participants
Moderate