Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

GnRH agonist plus chemotherapy vs chemotherapy alone

Pregnancy · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy showed no clear difference in pregnancy compared with chemotherapy alone (low certainty).

1 finding from 1 review

Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
RR 1.59 [0.93, 2.7]
7 studies · 703 participants
Low

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Pregnancy · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes pregnancy compared with chemotherapy alone (very low certainty).

1 finding from 1 review

Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
RR 3 [0.13, 70.3]
1 study · 50 participants
Very low