Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Skin

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

Glycolic acid (alpha‐hydroxy acid) vs salicylic‐mandelic acid

Participants' global self‐assessment of acne improvement Fair to good improvement (long term: treatment duration > 8 weeks) · participants with acne

Glycolic acid (alpha‐hydroxy acid) showed no clear difference in participants' global self‐assessment of acne improvement Fair to… compared with salicylic‐mandelic acid (low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 1.06 [0.88, 1.26]
1 study · 40 participants
Low

Glycolic acid (alpha‐hydroxy acid) vs salicylic‐mandelic acid

Treatment withdrawal · participants with acne

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 84 participants
Low

Glycolic acid (alpha‐hydroxy acid) vs salicylic‐mandelic acid

Minor adverse events · participants with acne

It is very uncertain whether glycolic acid (alpha‐hydroxy acid) changes total number of participants who experienced at least one minor… compared with salicylic‐mandelic acid (very low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 1.8 [0.72, 4.52]
1 study · 44 participants
Very low