Genome-wide common variants (additive dosage; GWAS meta-analysis) vs Genome-wide significance threshold (P<5E-8)
Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease cases vs controls
The meta-analysis found no novel loci for periodontal disease; the European SIGLEC5/chr19 locus did not replicate in Japanese populations; ungraded.
1 finding from 1 review
- Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese + European cohorts) · Meta-analysis: present study + GLIDE + UKB + BBJMeta-analysis of periodontal disease identified only previously known loci; no novel loci. The chromosome-19 SIGLEC5 locus associated with periodontitis in Europeans was not replicated in Japanese populations (present…4 studies · 764572 participantsGRADE not reported