What do systematic reviews say?

4 questions · 24 findings · 1 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 24 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

GG genotype of ENAM rs3796704 vs AA + AG genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA + AG genotype of ENAM rs3796704 and dental caries susceptibility (GG vs AA + AG model: OR 1.05, 95% CI 0.66-1.68) in the Control group: Low caries subgroup; certainty not graded.

6 findings from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Low caries
OR 1.05 [0.66, 1.68]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Mixed
OR 1.43 [0.67, 3.05]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Overall
OR 1.41 [1.06, 1.87]
4 studies · 1107 participants
GRADE not reported

Show 3 more findings

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Caucasian
OR 1.41 [1.04, 1.91]
3 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Age group: Children
OR 1.71 [1.02, 2.85]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Caries-free
OR 1.67 [1.17, 2.39]
2 studies
GRADE not reported

AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG genotype vs AA genotype of ENAM rs3796704 and dental caries susceptibility (AG vs AA model: OR 0.35, 95% CI 0.07-1.74) in the Age group: Children subgroup; certainty not graded.

6 findings from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Age group: Children
OR 0.35 [0.07, 1.74]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Overall
OR 1.27 [0.64, 2.52]
4 studies · 1107 participants
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Caries-free
OR 1.74 [0.81, 3.74]
2 studies
GRADE not reported

Show 3 more findings

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Caucasian
OR 1.74 [0.81, 3.74]
3 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Mixed
OR 0.14 [0.01, 1.46]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Low caries
OR 0.14 [0.01, 1.46]
2 studies
GRADE not reported

GG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA genotype of ENAM rs3796704 and dental caries susceptibility (GG vs AA model: OR 1.86, 95% CI 0.96-3.62); certainty not graded.

6 findings from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Overall
OR 1.86 [0.96, 3.62]
4 studies · 1107 participants
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Caries-free
OR 2.499 [1.19, 5.24]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Age group: Children
OR 0.61 [0.13, 2.93]
2 studies
GRADE not reported

Show 3 more findings

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Caucasian
OR 2.49 [1.19, 5.24]
3 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Mixed
OR 0.27 [0.03, 2.47]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Low caries
OR 0.27 [0.03, 2.47]
2 studies
GRADE not reported

AG + GG genotype (G-allele carriers) of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs3796704 and dental caries susceptibility (AG + GG vs AA model: OR 0.24, 95% CI 0.03-2.17) in the Ethnicity: Mixed subgroup; certainty not graded.

6 findings from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Mixed
OR 0.24 [0.03, 2.17]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Overall
OR 1.64 [0.86, 3.14]
4 studies · 1107 participants
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Ethnicity: Caucasian
OR 2.16 [1.05, 4.45]
3 studies
GRADE not reported

Show 3 more findings

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Low caries
OR 0.24 [0.03, 2.17]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Control group: Caries-free
OR 2.16 [1.05, 4.45]
2 studies
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Case-control genetic association studies (multiple countries) · Age group: Children
OR 0.54 [0.11, 2.56]
2 studies
GRADE not reported