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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 6 · 85.7%High 0 · 0%

Folic or folinic acid (any) vs placebo

Gastrointestinal adverse events · Patients receiving methotrexate for rheumatoid arthritis

Folic or folinic acid (any) probably leads to lower GI side effects (nausea, vomiting, abdominal pain) compared with placebo (moderate certainty).

1 finding from 1 review

Folic or folinic acid (any) vs placebo

Stomatitis / mouth sores (incidence) · Patients receiving methotrexate for rheumatoid arthritis

Folic or folinic acid (any) showed no clear difference in stomatitis / mouth sores (incidence) compared with placebo (moderate certainty).

1 finding from 1 review

Folic or folinic acid (any) vs placebo

Liver toxicity (incidence of transaminase elevation) · Patients receiving methotrexate for rheumatoid arthritis

Folic or folinic acid (any) probably leads to lower liver toxicity (incidence of transaminase elevation) compared with placebo (moderate certainty).

1 finding from 1 review

Folic or folinic acid (any) vs placebo

Haematological disorders (neutropenia, etc) · Patients receiving methotrexate for rheumatoid arthritis

Folic or folinic acid (any) showed no clear difference in haematological disorders (neutropenia, etc) compared with placebo (low certainty).

1 finding from 1 review