Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Common Mental Disorders

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 100%High 0 · 0%

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine probably leads to higher failure to respond (reduction ≥ 50% on HDRS) compared with venlafaxine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.29 [1.1, 1.51]
12 studies · 3387 participants
Moderate

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 3097 participants
Moderate

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with venlafaxine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.89 [0.74, 1.06]
14 studies · 2683 participants
Moderate

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with venlafaxine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.31 [0.91, 1.89]
13 studies · 2640 participants
Moderate

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine probably leads to lower failure to complete ‐ side effects ‐ compared with venlafaxine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.72 [0.56, 0.94]
13 studies · 2640 participants
Moderate