What do systematic reviews say?

Fluoxetine vs citalopram

It is very uncertain whether fluoxetine changes failure to respond (reduction ≥ 50% on HDRS) compared with citalopram (very low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.6 [0.2, 1.79]
  1 study · 59 participants
  Very low

Fluoxetine vs citalopram

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 661 participants
  Moderate

Fluoxetine vs citalopram

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with citalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.87 [0.6, 1.27]
  3 studies · 732 participants
  Moderate

Fluoxetine vs citalopram

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with citalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.87 [0.48, 1.56]
  3 studies · 732 participants
  Moderate

Fluoxetine vs citalopram

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with citalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.64 [0.34, 1.2]
  3 studies · 732 participants
  Moderate

Fluoxetine vs escitalopram

Fluoxetine showed no clear difference in failure to respond (reduction ≥ 50% on HDRS) compared with escitalopram (low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.02 [0.56, 1.85]
  1 study · 240 participants
  Low

Fluoxetine vs escitalopram

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 231 participants
  Low

Fluoxetine vs escitalopram

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with escitalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.53 [1, 2.37]
  2 studies · 578 participants
  Moderate

Fluoxetine vs escitalopram

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with escitalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.74 [0.46, 6.53]
  2 studies · 578 participants
  Moderate

Fluoxetine vs escitalopram

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with escitalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.17 [0.64, 2.12]
  2 studies · 578 participants
  Moderate