Findings

What do systematic reviews say?

4 questions · 5 findings · 1 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Quantitative light-induced fluorescence (QLF) change · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

Adding CPP-ACP to fluorides did not significantly change QLF outcomes for smooth-surface early caries lesions versus fluorides alone; not GRADE-rated.

1 finding from 1 review

Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and… 2018 All outcomes
Post-treatment (4-12 weeks) · In vivo clinical trial (human oral cavity; smooth-surface early caries lesions) · Location of lesions: smooth surfaces
MD 0.26 [-0.50, 1.01]
2 studies
GRADE not reported

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Visual inspection scores · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

Two trials reported visual inspection scores but could not be pooled (different criteria, missing standard deviations) and gave inconsistent findings, so no quantitative conclusion could be drawn.

1 finding from 1 review

Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and… 2018 All outcomes
Post-treatment (4-24 weeks) · In vivo clinical trial (human oral cavity)
Not pooled (2 trials, different scoring criteria, standard deviations not reported). Brochner 2011: no significant difference; Andersson 2007: more lesions became invisible with fluorides + CPP-ACP.
2 studies
GRADE not reported

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Laser fluorescence (LF) change · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

For occlusal early caries lesions, adding CPP-ACP to fluorides produced significantly greater laser-fluorescence improvement than fluorides alone (favors the combination); not GRADE-rated.

2 findings from 1 review

Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and… 2018 All outcomes
Post-treatment (3-12 weeks) · In vivo clinical trial (human oral cavity; occlusal early caries lesions) · Location of lesions: occlusal surfaces
MD -21.02 [-27.94, -14.10]
3 studies
GRADE not reported
Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and… 2018 All outcomes
Post-treatment (12-24 weeks) · In vivo clinical trial (human oral cavity; smooth-surface early caries lesions) · Location of lesions: smooth surfaces
MD -13.90 [-39.25, 11.46]
4 studies
GRADE not reported

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Total lesion area divided by total surface area (visual) · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

Adding CPP-ACP to fluorides did not significantly change the lesion-area outcome for smooth-surface early caries lesions versus fluorides alone; not GRADE-rated.

1 finding from 1 review

Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and… 2018 All outcomes
Post-treatment (8-24 weeks) · In vivo clinical trial (human oral cavity; smooth-surface early caries lesions; visual measurement) · Location of lesions: smooth surfaces
MD 4.37 [-0.51, 9.26]
2 studies
GRADE not reported