Fluoride-releasing primers/adhesives (Opal Seal; Clearfil Protect Bond) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control
Enamel demineralization (DIAGNOdent score) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Across three small non-randomized studies, fluoride-releasing primers (Opal Seal, Clearfil) showed no consistent clinical advantage over conventional primers in preventing white spot lesions (ungraded).
1 finding from 1 review
- Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes8 weeks to full treatment (to debonding) · Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adultsThree non-randomized studies (Comert 2020 n=56; Oz 2019 n=35; Oz 2017 n=15) showed no consistent clinical advantage. Comert: no significant difference in photographic WSL severity or area, although DIAGNOdent favored…3 studies · 106 participantsGRADE not reported