Fluoride agent (e.g., NaF/SDF/KF/CaF2) vs No biomimetic remineralization (control)
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Etch-and-Rinse adhesive + biological ACAD protocol network, Fluorine showed 4.197 MPa higher 24 h bond strength than Control (MD 4.197, 95% CI 1.080 to 7.314; Moderate certainty).
3 findings from 1 review
- Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. 2025 All outcomes24 h (immediate) · In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS) · Etch-and-Rinse + biological ACADMD 4.197 [1.080, 7.314]4 studiesModerate
- Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. 2025 All outcomes24 h (immediate) · In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS) · Etch-and-Rinse + chemical ACADMD -0.120 [-3.783, 3.544]8 studiesVery low
- Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. 2025 All outcomes24 h (immediate) · In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS) · Self-Etch + chemical ACADMD -0.601 [-2.932, 1.730]8 studiesModerate