Findings

What do systematic reviews say?

3 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 1 · 25%Very low 0 · 0%Low 3 · 75%Moderate 0 · 0%High 0 · 0%

Fluorescence-based devices vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity for detection of enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)

Fluorescence-based devices had a summary sensitivity of 0.76 (95% CrI 0.68, 0.82) for detecting enamel caries; low certainty.

2 findings from 1 review

Enamel Caries Detection and Diagnosis: An Analysis of Systematic Reviews. 2022 All outcomes
General dental practice; in vitro (extracted teeth) and in vivo (clinical) studies · Analysis 2: network meta-analysis (all studies evaluating >=2 index tests)
Sensitivity 0.76 [0.68, 0.82]
64 studies · 24567 participants
Low
Enamel Caries Detection and Diagnosis: An Analysis of Systematic Reviews. 2022 All outcomes
General dental practice; in vitro (extracted teeth) and in vivo (clinical) studies · Analysis 1: fully within-person comparison (studies evaluating >=3 index tests)
Sensitivity 0.71 [0.59, 0.81]
19 studies · 2849 participants
GRADE not reported

All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity at fixed median specificity 0.78 (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…

1 finding from 1 review

Fluorescence devices for the detection of dental caries 2020 · Cochrane All outcomes
Up to 3 months between index test and reference standard (in vivo studies)
Sensitivity 0.70 [0.64, 0.75]
79 studies
Low

All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity at fixed upper-quartile specificity 0.90 (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…

1 finding from 1 review

Fluorescence devices for the detection of dental caries 2020 · Cochrane All outcomes
Up to 3 months between index test and reference standard (in vivo studies)
Sensitivity 0.60 [0.54, 0.65]
79 studies
Low