What do systematic reviews say?

Fish oil lipid emulsion (LE) vs non‐fish oil LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 347 participants
  Low

Fish oil lipid emulsion (LE) vs another fish oil LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 0.96 [0.06, 14.65]
  1 study · 55 participants
  Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1 [0.15, 6.64]
  1 study · 60 participants
  Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Fish oil lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MOFS‐LE vs… compared with another fish oil LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.16 [0.4, 3.35]
  1 study · 55 participants
  Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Fish oil lipid emulsion (LE) showed no clear difference in any sepsis (clinical or culture positive (or both)) – MOFS‐LE vs… compared with another fish oil LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.69 [0.56, 5.11]
  1 study · 55 participants
  Low

Fish oil lipid emulsion (LE) vs another fish oil LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 0.54 [0.32, 0.91]
  2 studies · 40 participants
  Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

It is very uncertain whether fish oil lipid emulsion (LE) changes death before discharge – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 0.24 [0.03, 1.87]
  2 studies · 40 participants
  Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

It is very uncertain whether fish oil lipid emulsion (LE) changes any sepsis – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.21 [0.5, 2.92]
  2 studies · 40 participants
  Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs S‐LE compared with non‐fish oil LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.24 [0.81, 1.9]
  9 studies · 855 participants
  Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Fish oil lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MOFS‐LE vs… compared with non‐fish oil LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1 [0.75, 1.34]
  6 studies · 581 participants
  Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 673 participants
  Low