Findings

What do systematic reviews say?

55 questions · 56 findings · 4 reviews

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No studies found 0 · 0%GRADE not reported 7 · 12.5%Very low 25 · 44.6%Low 24 · 42.9%Moderate 0 · 0%High 0 · 0%

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · parenterally fed preterm infants with surgical conditions

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Neurodevelopmental outcomes · parenterally fed preterm infants with surgical conditions

2 findings from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 11 participants
GRADE not reported
Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 10 participants
GRADE not reported

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Resolution of PNALD/ cholestasis (conjugated bilirubin < 2 mg/dL) Pure F‐LE vs Intralipid · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes resolution of PNALD/ cholestasis (conjugated bilirubin < 2 mg/dL)… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 5.6 [0.34, 93.35]
1 study · 16 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.54 [0.32, 0.91]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (any definition): combined subgroups (all studies) – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/cholestasis (any definition): combined subgroups (all studies)… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.63 [0.43, 0.91]
11 studies · 1154 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Growth · parenterally fed preterm infants with cholestasis

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Growth velocity, head circumference, mm/d, end of intervention · parenterally fed preterm infants with cholestasis

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Death of baby (up to discharge) · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes death before discharge – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.24 [0.03, 1.87]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Any sepsis – MOFS‐LE vs S‐LE – Pure F‐LE vs IL · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes any sepsis – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.21 [0.5, 2.92]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · parenterally fed preterm infants with cholestasis

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Death of baby (up to discharge) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs S‐LE compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.24 [0.81, 1.9]
9 studies · 855 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

ROP ≥ stage 3 or requiring surgery – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

It is very uncertain whether fish oil lipid emulsion (LE) changes ROP ≥ stage 3 or requiring surgery – all fish oil LE vs non‐fish oil… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.8 [0.55, 1.16]
7 studies · 731 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MOFS‐LE vs… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.75, 1.34]
6 studies · 581 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Culture‐positive sepsis · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in culture‐positive sepsis – fish oil LE vs non‐fish oil LE compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.16 [0.91, 1.48]
7 studies · 774 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 673 participants
Low