Findings

What do systematic reviews say?

28 questions · 28 findings · 1 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 3 · 10.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 8 · 28.6%Moderate 17 · 60.7%High 0 · 0%

First‐line thiazides vs alpha‐blocker

Withdrawals due to adverse events · patients with hypertension

First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 3.2 years compared with first‐line alpha‐blockers (low certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 0.7 [0.54, 0.89]
3 studies · 24772 participants
Low

First‐line thiazides vs beta‐blocker

Cardiovascular events · patients with hypertension

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 18135 participants
Moderate

First‐line thiazides vs beta‐blocker

Stroke · patients with hypertension

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 18135 participants
Low

First‐line thiazides vs beta‐blocker

Total CHD Duration: 1 to 5.8 years · patients with hypertension

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 18135 participants
Low

First‐line thiazides vs beta‐blocker

Congestive heart failure · patients with hypertension

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 6569 participants
Low

First‐line thiazides vs beta‐blocker

Adverse effects (side effects; treatment withdrawals) · patients with hypertension

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 18501 participants
Moderate

First‐line thiazides vs calcium channel blockers

Total mortality Duration: 1 to 5 years · patients with hypertension

First‐line thiazides showed no clear difference in total mortality Duration: 1 to 5 years compared with first‐line calcium channel blockers (moderate certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 1.02 [0.96, 1.08]
7 studies · 35417 participants
Moderate

First‐line thiazides vs calcium channel blockers

Total serious adverse events Duration: 1.75 to 3 years · patients with hypertension

First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 1.09 [0.97, 1.24]
2 studies · 7204 participants
Low