Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Fibrinolytics vs placebo

Referral for thoracic surgery (open or thorascopic) · adult parapneumonic effusions and empyema

Fibrinolytics may leads to lower referral for thoracic surgery. compared with placebo (low certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 0.37 [0.21, 0.68]
8 studies · 897 participants
Low

Fibrinolytics vs placebo

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

It is very uncertain whether fibrinolytics changes overall treatment failure, including mortality, thoracic surgery or… compared with placebo (very low certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 0.16 [0.05, 0.58]
7 studies · 769 participants
Very low