Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 1 · 33.3%Very low 1 · 33.3%Low 0 · 0%Moderate 1 · 33.3%High 0 · 0%

Fibrinolytics vs placebo

Mortality. · adult parapneumonic effusions and empyema

Fibrinolytics showed no clear difference in mortality. compared with placebo (moderate certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 1.16 [0.71, 1.91]
8 studies · 867 participants
Moderate

Fibrinolytics vs placebo

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

It is very uncertain whether fibrinolytics changes overall treatment failure, including mortality, thoracic surgery or… compared with placebo (very low certainty).

1 finding from 1 review

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
OR 0.16 [0.05, 0.58]
7 studies · 769 participants
Very low

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo

Mortality (all‐cause) ‐ not reported · People with a haematological disorder

1 finding from 1 review

Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported