What do systematic reviews say?

Esketamine vs placebo

Esketamine probably leads to higher efficacy: number of participants who achieve remission ‐ at 24 hours… compared with placebo (moderate certainty).

• Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
  OR 2.74 [1.71, 4.4]
  Studies not reported
  Moderate