What do systematic reviews say?

Esketamine vs placebo

Esketamine showed no clear difference in acceptability: total dropouts№ of participants: 773(5 RCTs) compared with placebo (moderate certainty).

• Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
  OR 1.58 [0.92, 2.73]
  Studies not reported
  Moderate