Findings

What do systematic reviews say?

6 questions · 7 findings · 1 reviews · Common Mental Disorders

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 3 · 42.9%High 2 · 28.6%

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Outcomes (2‐6 months post‐treatment) · adults with panic disorder

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors may leads to lower failure to respond compared with placebo (low certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.61 [0.41, 0.91]
4 studies · 1531 participants
Low

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Leaving the study early · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors showed no clear difference in total number of dropouts compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.93 [0.69, 1.26]
4 studies · 1531 participants
Moderate

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Failure to remit at endpoint · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors probably leads to lower failure to remit compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.84 [0.75, 0.95]
4 studies · 1531 participants
Moderate

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 723 participants
High
Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 685 participants
High

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Withdrawals due to adverse events · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors showed no clear difference in number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.49 [0.92, 2.4]
4 studies · 1531 participants
Moderate