Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

115 questions · 122 findings · 10 reviews

No studies found 34 · 27.9%GRADE not reported 14 · 11.5%Very low 31 · 25.4%Low 24 · 19.7%Moderate 17 · 13.9%High 2 · 1.6%

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

0.5% bupivacaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
  • 'Other comparisons with 100% success': IANB - Sampaio 2012 35/35 vs 35/35; Fernandez 2005 39/39 vs 39/39. Both formulations 100% successful; no meta-analysis (no difference).
    2 studies · 74 participants
    GRADE not reported

Bupivicaine plus epinephrine vs placebo to reduce blood loss during myomectomy

Blood loss (ml) Estimated blood loss during myomectomy · women with uterine fibroids

Bupivicaine plus epinephrine showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo to reduce blood loss during myomectomy (low certainty).

1 finding from 1 review

4% prilocaine, 1:200,000 epinephrine vs 4% prilocaine plain

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% prilocaine, 1:200,000 epinephrine may leads to higher duration of anaesthesia (soft tissue, simulated) compared with 4% prilocaine plain (low certainty).

1 finding from 1 review