Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Vascular

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%

All‐cause mortality · atherosclerotic cardiovascular disease

EDTA showed no clear difference in all‐cause mortality compared with placebo (low certainty).

1 finding from 1 review

Chelation therapy for atherosclerotic cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 0.97 [0.73, 1.28]
2 studies · 1792 participants
Low

Coronary heart disease mortality – CHD deaths · atherosclerotic cardiovascular disease

It is very uncertain whether EDTA changes coronary heart disease death compared with placebo (very low certainty).

1 finding from 1 review

Chelation therapy for atherosclerotic cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 1.02 [0.7, 1.48]
1 study · 1708 participants
Very low

Myocardial infarction · atherosclerotic cardiovascular disease

EDTA showed no clear difference in myocardial infarction compared with placebo (moderate certainty).

1 finding from 1 review

Chelation therapy for atherosclerotic cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 0.81 [0.57, 1.14]
2 studies · 1792 participants
Moderate

Angina · atherosclerotic cardiovascular disease

It is very uncertain whether EDTA changes angina compared with placebo (very low certainty).

1 finding from 1 review

Chelation therapy for atherosclerotic cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 0.95 [0.55, 1.67]
2 studies · 1792 participants
Very low

Stroke · atherosclerotic cardiovascular disease

EDTA showed no clear difference in stroke compared with placebo (low certainty).

1 finding from 1 review

Chelation therapy for atherosclerotic cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 0.88 [0.4, 1.92]
2 studies · 1867 participants
Low

Ankle brachial index · atherosclerotic cardiovascular disease

1 finding from 1 review

Chelation therapy for atherosclerotic cardiovascular disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 181 participants
Low

Maximum walking distance · atherosclerotic cardiovascular disease

1 finding from 1 review

Chelation therapy for atherosclerotic cardiovascular disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 165 participants
Low