Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · All outcomes

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

E-cigarette aerosol / e-liquid exposure (flavored and unflavored; nicotine and non-nicotine) vs Unexposed controls / unflavored e-liquid / conventional cigarette smoke

Enamel/dental hard-tissue changes and e-liquid cariogenic properties (demineralization, colour change, pH, sugar content, metals) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…

In vitro evidence suggests e-liquids are often acidic and sugar-containing and can alter enamel/dentin colour and properties, supporting a plausible cariogenic effect, but findings are heterogeneous and not pooled (ungraded, narrative).

1 finding from 1 review

The effects of electronic smoking on dental caries and proinflammatory markers: a systematic review and meta-analysis. 2025 All outcomes
Laboratory (in vitro/ex vivo) studies of oral bacteria and dental hard tissue, plus a few clinical oral-microbiome studies
Narrative synthesis. In vitro studies showed e-liquids can be acidic (Fairchild 2021: 84% of vapes pH<5.5) and contain sugars (Fagan 2018 sucrose ~125 ug/ml; Kubica 2014 sucrose 0.76-72.93 ug/g), and e-cigarette…
Studies not reported
GRADE not reported

E-cigarette aerosol / e-liquid exposure (flavored and unflavored; nicotine and non-nicotine) vs Unexposed controls / unflavored e-liquid / conventional cigarette smoke

Cariogenic and commensal oral bacteria (S. mutans and commensal streptococci growth, adhesion, biofilm) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…

Most in vitro studies indicate e-cigarette aerosol/e-liquid (especially flavored/high-concentration) disrupts normal oral flora and favors cariogenic S. mutans growth and biofilm, plausibly increasing caries risk; not pooled (ungraded, narrative).

1 finding from 1 review

The effects of electronic smoking on dental caries and proinflammatory markers: a systematic review and meta-analysis. 2025 All outcomes
Laboratory (in vitro/ex vivo) studies of oral bacteria and dental hard tissue, plus a few clinical oral-microbiome studies
Narrative synthesis of 9 studies (Table 2). E-cigarette aerosol/e-liquid at higher concentrations (>=5%) and flavored liquids inhibited commensal oral streptococci and allowed S. mutans to proliferate, with increased…
9 studies
GRADE not reported