Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Skin

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No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 12.5%High 4 · 50%

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in physician‐assessed improvement in rosacea severity Investigator's… compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 1.08 [0.93, 1.27]
1 study · 207 participants
High

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Clinician's Erythema Assessment ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Lesion count · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 207 participants
Moderate

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Time needed until improvement · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 207 participants
High

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in participant‐assessed improvement in rosacea severity Excellent… compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 1.05 [0.79, 1.4]
1 study · 207 participants
High

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Proportion of participants with adverse event · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in proportion of participants with adverse event compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 0.27 [0.06, 1.28]
1 study · 207 participants
High