Findings

What do systematic reviews say?

3 questions · 8 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 6 · 75%Very low 2 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 0.34 [-0.08, 0.76]
3 studies · 75 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD 1.10 [0.36, 1.84]
1 study · 27 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.12 [-0.72, 0.49]
2 studies · 49 participants
GRADE not reported

Clinical attachment level (CAL) · Adults with aggressive periodontitis

It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -0.80 [-1.49, -0.11]
1 study · 22 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.61 [-1.14, -0.08]
3 studies · 65 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.15 [-0.53, 0.83]
2 studies · 43 participants
GRADE not reported

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 0.17 [-1.28, 1.62]
1 study · 20 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.20 [0.06, 0.33]
2 studies · 50 participants
GRADE not reported