Findings

What do systematic reviews say?

3 questions · 4 findings · 1 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 1 · 25%High 1 · 25%

Dornase alfa vs placebo or no dornase alfa treatment

FEV1 % predicted: relative change from baseline · adults and children with cystic fibrosis

2 findings from 1 review

Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 320 participants
Moderate
Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 647 participants
High

Dornase alfa vs hypertonic saline

FEV1 · children with cystic fibrosis

Dornase alfa may leads to higher mean relative percentage in FEV1 (L) at 3 months compared with hypertonic saline (low certainty).

1 finding from 1 review

Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
MD 8 [2, 14]
431 participants
Low

Dornase alfa vs alternate days

FEV1 · children with cystic fibrosis

Dornase alfa daily showed no clear difference in mean relative percentage change in FEV1 (L) at 3 months compared with alternate days (low certainty).

1 finding from 1 review

Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
MD 2
43 participants
Low