What do systematic reviews say?

Donepezil 23 mg/day vs donepezil 10 mg/day

Donepezil 23 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with donepezil 10 mg/day (moderate certainty).

• Donepezil for dementia due to Alzheimer's disease 2018 · Cochrane Headline outcomes only
  OR 2.02 [1.59, 2.57]
  2 studies · 1818 participants
  Moderate

Donepezil 23 mg/day vs donepezil 10 mg/day

Donepezil 23 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 24 weeks) compared with donepezil 10 mg/day (moderate certainty).

• Donepezil for dementia due to Alzheimer's disease 2018 · Cochrane Headline outcomes only
  OR 1.65 [1.34, 2.03]
  2 studies · 1785 participants
  Moderate

Donepezil 23 mg/day vs donepezil 10 mg/day

• Donepezil for dementia due to Alzheimer's disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1704 participants
  Moderate