What do systematic reviews say?

Donepezil 10 mg/day vs placebo

Donepezil 10 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with placebo (moderate certainty).

• Donepezil for dementia due to Alzheimer's disease 2018 · Cochrane Headline outcomes only
  OR 1.25 [1.05, 1.5]
  12 studies · 2846 participants
  Moderate

Donepezil 10 mg/day vs placebo

Donepezil 10 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 26 weeks) compared with placebo (moderate certainty).

• Donepezil for dementia due to Alzheimer's disease 2018 · Cochrane Headline outcomes only
  OR 1.59 [1.31, 1.95]
  10 studies · 2500 participants
  Moderate

Donepezil 10 mg/day vs placebo

• Donepezil for dementia due to Alzheimer's disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 815 participants
  Moderate