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Evidence found and GRADE certainty

36 questions · 44 findings · 2 reviews · Pain, Palliative and Supportive Care

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No studies found 6 · 13.6%GRADE not reported 14 · 31.8%Very low 13 · 29.5%Low 9 · 20.5%Moderate 2 · 4.5%High 0 · 0%

Diclofenac vs opioid

Nausea and vomiting · children with acute postoperative pain

Diclofenac probably leads to lower nausea, vomiting, or both during study period № of participants: 463… compared with opioids (moderate certainty).

1 finding from 1 review

Diclofenac vs opioid

Any bleeding during study period № of participants: 100(2 RCTs)d · children with acute postoperative pain

Diclofenac probably leads to higher any bleeding during study period № of participants: 222 (2 RCTs) compared with opioids (moderate certainty).

1 finding from 1 review

Diclofenac vs paracetamol

Nausea and vomiting · children with acute postoperative pain

It is very uncertain whether diclofenac changes nausea, vomiting, or both during study period № of participants: 348… compared with paracetamol (very low certainty).

1 finding from 1 review

Diclofenac vs paracetamol

Any bleeding during study period № of participants: 100(2 RCTs)d · children with acute postoperative pain

It is very uncertain whether diclofenac changes any bleeding during study period № of participants: 332 (5 RCTs) compared with paracetamol (very low certainty).

1 finding from 1 review

Diclofenac vs paracetamol

Serious adverse events during the study period · children with acute postoperative pain

It is very uncertain whether diclofenac changes serious adverse events during study period № of participants: 60 (1… compared with paracetamol (very low certainty).

1 finding from 1 review

Diclofenac vs bupivacaine

Nausea and vomiting · children with acute postoperative pain

It is very uncertain whether diclofenac changes nausea, vomiting, or both during study period № of participants: 128… compared with bupivacaine (very low certainty).

1 finding from 1 review

Diclofenac vs bupivacaine

Any bleeding during study period № of participants: 100(2 RCTs)d · children with acute postoperative pain

It is very uncertain whether diclofenac changes any bleeding during study period № of participants: 38 (1 RCTs) compared with bupivacaine (very low certainty).

1 finding from 1 review