Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Mortality at any time point · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Low

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Responder analysis · people with transfusion‐dependent thalassemia

The review found no eligible studies for this question.

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Serum ferritin (ng/mL): mean change from baseline · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Very low

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

LIC · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Low

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Satisfaction · people with transfusion‐dependent thalassemia

The review found no eligible studies for this question.

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Adherence: Discontinuations · people with transfusion‐dependent thalassemia

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Very low

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Drug‐related AE: serum creatinine increased (≥ 33%) above baseline in 2 consecutive occasions · people with transfusion‐dependent thalassemia

It is very uncertain whether deferasirox and deferiprone changes drug‐related AE: serum creatinine increased (≥ 33%) above baseline… compared with deferiprone and deferoxamine (very low certainty).

1 finding from 1 review

Deferasirox for managing iron overload in people with thalassaemia 2017 · Cochrane Headline outcomes only
RR 3 [0.32, 27.83]
1 study · 96 participants
Very low