Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Injuries

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No studies found 1 · 12.5%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 5 · 62.5%Moderate 1 · 12.5%High 0 · 0%

DDAVP vs tranexamic acid (control)

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

It is very uncertain whether DDAVP changes number of participants receiving a red cell transfusion (total) compared with tranexamic acid (very low certainty).

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
RR 2.42 [1.04, 5.64]
3 studies · 135 participants
Very low

DDAVP vs placebo or usual care

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

DDAVP showed no clear difference in number of participants receiving a red cell transfusion (total) compared with placebo or standard care (moderate certainty).

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
RR 0.96 [0.86, 1.06]
25 studies · 1806 participants
Moderate

DDAVP vs aprotinin

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

DDAVP may leads to higher number of participants receiving a red cell transfusion (total) compared with aprotinin (low certainty).

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
RR 2.41 [1.45, 4.02]
1 study · 99 participants
Low

DDAVP vs placebo or usual care

Number of participants receiving a red cell transfusion (total) · participants with platelet dysfunction undergoing surgery

DDAVP showed no clear difference in number of participants receiving a red cell transfusion (total) compared with placebo or standard care: platelet dysfunction subgroup (low certainty).

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
RR 0.83 [0.66, 1.04]
5 studies · 258 participants
Low

DDAVP vs placebo or usual care

Red cell volume transfused (total) · participants undergoing surgery

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
no estimate extracted
23 studies · 1454 participants
Low

DDAVP vs tranexamic acid (control)

Red cell volume transfused (total) · participants undergoing surgery

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

DDAVP vs aprotinin

Red cell volume transfused (total) · participants undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

DDAVP vs placebo or usual care

Red cell volume transfused (total) · participants with platelet dysfunction undergoing surgery

1 finding from 1 review

Desmopressin use for minimising perioperative blood transfusion 2017 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 388 participants
Low