Cytarabine plus high‐dose methotrexate vs high‐dose methotrexate alone
Severe adverse effects (grade 3+): Infection · patients with primary CNS lymphoma
Cytarabine plus high‐dose methotrexate probably leads to higher infections (grade 3 to 4) compared with high‐dose methotrexate alone (moderate certainty).
1 finding from 1 review
- Role of chemotherapy additional to high‐dose methotrexate for primary central nervous system lymphoma (PCNSL) 2012 · Cochrane Headline outcomes onlyRR 9.23 [1.23, 69.47]1 study · 79 participantsModerate