Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Kidney and Transplant

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No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 2 · 33.3%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Cyclosporin plus prednisolone vs prednisolone

Clinical relapse · SSNS in children

Cyclosporin plus prednisolone may leads to lower relapse at 6 months compared with prednisolone alone (low certainty).

1 finding from 1 review

Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children 2020 · Cochrane Headline outcomes only
RR 0.33 [0.13, 0.83]
1 study · 104 participants
Low

Cyclosporin plus prednisolone vs prednisolone

Relapse · SSNS in children

Cyclosporin plus prednisolone showed no clear difference in relapse at 12 months compared with prednisolone alone (low certainty).

1 finding from 1 review

Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children 2020 · Cochrane Headline outcomes only
RR 0.72 [0.46, 1.13]
1 study · 104 participants
Low

Cyclosporin plus prednisolone vs prednisolone

Frequent relapses · SSNS in children

The review found no eligible studies for this question.

1 finding from 1 review

Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cyclosporin plus prednisolone vs prednisolone

Mean relapse rate/patient/month · SSNS in children

The review found no eligible studies for this question.

1 finding from 1 review

Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cyclosporin plus prednisolone vs prednisolone

Adverse effects: number needing cytotoxic agents · SSNS in children

It is very uncertain whether cyclosporin plus prednisolone changes adverse effects: number needing cytotoxic agents compared with prednisolone alone (very low certainty).

1 finding from 1 review

Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children 2020 · Cochrane Headline outcomes only
RR 0.47 [0.18, 1.23]
1 study · 104 participants
Very low

Cyclosporin plus prednisolone vs prednisolone

Adverse effects: creatinine at the end of study · SSNS in children

1 finding from 1 review

Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Very low