Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Childhood Cancer

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No studies found 4 · 57.1%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Continuous platinum infusion vs bolus platinum infusion

Hearing loss · children with cancer treated with platinum‐based therapy

Continuous platinum infusion showed no clear difference in hearing loss (asymptomatic and symptomatic disease according to… compared with bolus platinum infusion (low certainty).

1 finding from 1 review

Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only
RR 1.39 [0.47, 4.13]
1 study · 67 participants
Low

Continuous platinum infusion vs bolus platinum infusion

Tinnitus ‐ not reported · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous platinum infusion vs bolus platinum infusion

Overall survival ‐ not reported · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous platinum infusion vs bolus platinum infusion

Event‐free survival · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous platinum infusion vs bolus platinum infusion

Tumour response · children with cancer treated with platinum‐based therapy

1 finding from 1 review

Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Low

Continuous platinum infusion vs bolus platinum infusion

Adverse effects: toxic death (no definition provided) · children with cancer treated with platinum‐based therapy

Continuous platinum infusion showed no clear difference in adverse effects: toxic death (no definition provided) compared with bolus platinum infusion (low certainty).

1 finding from 1 review

Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only
RR 1.12 [0.07, 17.31]
1 study · 91 participants
Low

Continuous platinum infusion vs bolus platinum infusion

Quality of life ‐ not reported · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found