What do systematic reviews say?

Antipsychotics vs placebo

It is very uncertain whether comparison 2: Antipsychotics changes treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (very low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.51 [0.16, 1.67]
  2 studies · 43 participants
  Very low

Antipsychotics vs placebo

Comparison 2: Antipsychotics showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.98 [0.92, 1.05]
  5 studies · 348 participants
  Low

Antipsychotics vs placebo

It is very uncertain whether comparison 4: antipsychotics changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).

• Pharmacotherapy for social anxiety disorder (SAnD) 2017 · Cochrane Headline outcomes only
  RR 7 [0.45, 108.26]
  1 study · 10 participants
  Very low

Antipsychotics vs placebo

It is very uncertain whether comparison 4: antipsychotics changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

• Pharmacotherapy for social anxiety disorder (SAnD) 2017 · Cochrane Headline outcomes only
  RR 0.71 [0.06, 8.9]
  1 study · 12 participants
  Very low

Antipsychotics vs placebo

• Pharmacotherapy for social anxiety disorder (SAnD) 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 9 participants
  Very low