Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Eyes and Vision

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 3 · 50%High 0 · 0%

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

Tear film stability · people with dry eyea

Combined oral omega‐3 and omega‐6 PUFAs showed no clear difference in change in tear film stability, measured using tear break‐up time… compared with placebo (moderate certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
MD 0.55
4 studies · 455 participants
Moderate

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

Change in tear osmolarity (measured in mOsmol/L, with reductions in osmolarity indicating clinical improvement) at 1‐month (with actual · people with dry eyea

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 83 participants
Low

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

Adverse event: gastrointestinal disorders at 1‐month (with actual · people with dry eyea

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 138 participants
Low

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

Dry eye symptoms, measured using the OSDI score (ranging from 0 to 100 units, with a reduction in scores indicating clinical improvement) at 1‐month (with actual · people with dry eyea

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 4 participants
Low

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

Ocular surface staining · people with dry eyea

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 3 participants
Moderate

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

Aqueous tear production · people with dry eyea

Combined oral omega‐3 and omega‐6 PUFAs showed no clear difference in schirmer test (aqueous tear production, measured in mm/5 min, with… compared with placebo (moderate certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
MD 0.66
4 studies · 455 participants
Moderate