Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 3 · 60%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 1 · 20%High 0 · 0%

Combined immune checkpoint inhibitors (ICIs) vs chemotherapy alone

Health‐related quality of life · People with advanced non‐small cell lung cancer

The review found no eligible studies for this question.

1 finding from 1 review

Single or combined immune checkpoint inhibitors compared to first‐line platinum‐based chemotherapy with or without… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined immune checkpoint inhibitors (ICIs) vs chemotherapy alone

Overall survival (OS) · People with advanced non‐small cell lung cancer

Combined immune checkpoint inhibitors (ICIs) probably leads to lower overall Survival (OS) compared with chemotherapy (moderate certainty).

1 finding from 1 review

Single or combined immune checkpoint inhibitors compared to first‐line platinum‐based chemotherapy with or without… 2021 · Cochrane Headline outcomes only
HR 0.72 [0.59, 0.89]
2 studies · 612 participants
Moderate

Combined immune checkpoint inhibitors (ICIs) vs chemotherapy alone

Progression‐free survival · People with advanced non‐small cell lung cancer

The review found no eligible studies for this question.

1 finding from 1 review

Single or combined immune checkpoint inhibitors compared to first‐line platinum‐based chemotherapy with or without… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined immune checkpoint inhibitors (ICIs) vs chemotherapy alone

Overall response rate (OSR) · People with advanced non‐small cell lung cancer

The review found no eligible studies for this question.

1 finding from 1 review

Single or combined immune checkpoint inhibitors compared to first‐line platinum‐based chemotherapy with or without… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined immune checkpoint inhibitors (ICIs) vs chemotherapy alone

Grades 3 and 4 adverse events · People with advanced non‐small cell lung cancer

Combined immune checkpoint inhibitors (ICIs) showed no clear difference in adverse Events grade 3 to 4 compared with chemotherapy (low certainty).

1 finding from 1 review

Single or combined immune checkpoint inhibitors compared to first‐line platinum‐based chemotherapy with or without… 2021 · Cochrane Headline outcomes only
RR 0.78 [0.55, 1.09]
2 studies · 1869 participants
Low