Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Airways

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 4 · 80%High 0 · 0%

Combination fluticasone/salmeterol vs budesonide/formoterol

Number of participants experiencing one or more episode requiring treatment with oral steroids · adults and children with chronic asthma

Combination fluticasone/salmeterol showed no clear difference in participants experiencing exacerbations requiring oral steroid… compared with budesonide/formoterol (moderate certainty).

1 finding from 1 review

Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
OR 0.89 [0.74, 1.07]
4 studies · 4949 participants
Moderate

Combination fluticasone/salmeterol vs budesonide/formoterol

Hospital admissions due to exacerbations: number of participants · adults and children with chronic asthma

Combination fluticasone/salmeterol showed no clear difference in participants experiencing exacerbations requiring admission to… compared with budesonide/formoterol (moderate certainty).

1 finding from 1 review

Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
OR 1.29 [0.68, 2.47]
4 studies · 4879 participants
Moderate

Combination fluticasone/salmeterol vs budesonide/formoterol

Asthma‐related serious adverse event · adults and children with chronic asthma

Combination fluticasone/salmeterol showed no clear difference in asthma‐related serious adverse event compared with budesonide/formoterol (moderate certainty).

1 finding from 1 review

Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
OR 1.47 [0.75, 2.86]
3 studies · 4054 participants
Moderate

Combination fluticasone/salmeterol vs budesonide/formoterol

All‐cause mortality · adults and children with chronic asthma

1 finding from 1 review

Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 4819 participants
Low

Combination fluticasone/salmeterol vs budesonide/formoterol

Withdrawals due to adverse events · adults and children with chronic asthma

Combination fluticasone/salmeterol showed no clear difference in withdrawals (adverse events) compared with budesonide/formoterol (moderate certainty).

1 finding from 1 review

Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in… 2011 · Cochrane Headline outcomes only
OR 0.94 [0.6, 1.46]
5 studies · 5082 participants
Moderate