Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 70 findings · 7 reviews

No studies found 25 · 35.7%GRADE not reported 6 · 8.6%Very low 15 · 21.4%Low 18 · 25.7%Moderate 6 · 8.6%High 0 · 0%

Comparison 1.2: Group‐based CBT‐based psychotherapy vs TAU or another comparator

Repetition of SH at post‐intervention · self‐harm in adults

Comparison 1.2: Group‐based CBT‐based psychotherapy showed no clear difference in repetition of SH at post‐intervention compared with TAU or another comparator (moderate certainty).

1 finding from 1 review

COGNITIVE BEHAVIOUR THERAPY + MOTIVATIONAL INTERVIEWING vs usual care

Lost to treatment · people with both severe mental illness and substance misuse

Cognitive behavioural therapy + motivational interviewing showed no clear difference in leaving the study early: Lost to treatment compared with standard care (low certainty).

1 finding from 1 review

COGNITIVE BEHAVIOUR THERAPY + MOTIVATIONAL INTERVIEWING vs usual care

Adverse event: Death · people with both severe mental illness and substance misuse

Cognitive behavioural therapy + motivational interviewing showed no clear difference in adverse event: Death compared with standard care (low certainty).

1 finding from 1 review

COGNITIVE BEHAVIOUR THERAPY + MOTIVATIONAL INTERVIEWING vs usual care

Relapse · people with both severe mental illness and substance misuse

It is very uncertain whether cognitive behavioural therapy + motivational interviewing changes relapse:* Relapse at 3 months after 9 months of treatment compared with standard care (very low certainty).

1 finding from 1 review