Findings

What do systematic reviews say?

8 questions · 8 findings · 2 reviews · Oral medicine and oral cancer

No studies found 0 · 0%GRADE not reported 6 · 75%Very low 0 · 0%Low 2 · 25%Moderate 0 · 0%High 0 · 0%

Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy

Chlorhexidine showed no clear difference in oral candidiasis (present) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral candidiasis for patients with cancer receiving treatment 2007 · Cochrane All outcomes
RR 0.59 [0.19, 1.83]
3 studies · 115 participants
GRADE not reported

Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy

Chlorhexidine showed no clear difference in oral candidiasis (present) compared with chlorhexidine plus nystatin; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral candidiasis for patients with cancer receiving treatment 2007 · Cochrane All outcomes
RR 1.62 [0.64, 4.1]
1 study · 52 participants
GRADE not reported

Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy

Chlorhexidine showed no clear difference in oral candidiasis (present) compared with nystatin; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral candidiasis for patients with cancer receiving treatment 2007 · Cochrane All outcomes
RR 0.89 [0.36, 2.21]
1 study · 34 participants
GRADE not reported

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.76 [0.47, 1.24]
4 studies · 454 participants
Low

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 1.03 [0.76, 1.41]
1 study · 133 participants
GRADE not reported

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (moderate to severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 1.13 [0.64, 1.97]
1 study · 133 participants
GRADE not reported

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (severe) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.82 [0.54, 1.23]
4 studies · 244 participants
Low

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 1.16 [0.46, 2.92]
1 study · 133 participants
GRADE not reported