Findings

What do systematic reviews say?

11 questions · 11 findings · 3 reviews · All outcomes

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No studies found 0 · 0%GRADE not reported 9 · 81.8%Very low 0 · 0%Low 2 · 18.2%Moderate 0 · 0%High 0 · 0%

Chlorhexidine vs placebo/no treatment

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.76 [0.47, 1.24]
4 studies · 454 participants
Low

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 1.03 [0.76, 1.41]
1 study · 133 participants
GRADE not reported

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (moderate to severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 1.13 [0.64, 1.97]
1 study · 133 participants
GRADE not reported

Chlorhexidine vs placebo/no treatment

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (severe) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.82 [0.54, 1.23]
4 studies · 244 participants
Low

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 1.16 [0.46, 2.92]
1 study · 133 participants
GRADE not reported

Chlorhexidine vs placebo or no treatment

Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy

Chlorhexidine showed no clear difference in oral candidiasis (present) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral candidiasis for patients with cancer receiving treatment 2007 · Cochrane All outcomes
RR 0.59 [0.19, 1.83]
3 studies · 115 participants
GRADE not reported

Chlorhexidine vs Chlorhexidine plus nystatin

Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy

Chlorhexidine showed no clear difference in oral candidiasis (present) compared with chlorhexidine plus nystatin; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral candidiasis for patients with cancer receiving treatment 2007 · Cochrane All outcomes
RR 1.62 [0.64, 4.1]
1 study · 52 participants
GRADE not reported

Chlorhexidine vs Nystatin

Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy

Chlorhexidine showed no clear difference in oral candidiasis (present) compared with nystatin; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral candidiasis for patients with cancer receiving treatment 2007 · Cochrane All outcomes
RR 0.89 [0.36, 2.21]
1 study · 34 participants
GRADE not reported

Chlorhexidine mouthwash vs Salt and soda mouthwash

Mucositis eradicated · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Chlorhexidine mouthwash showed no clear difference in mucositis eradicated compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Interventions for treating oral mucositis for patients with cancer receiving treatment 2010 · Cochrane All outcomes
RR 1.10 [0.90, 1.35]
1 study · 138 participants
GRADE not reported

Chlorhexidine mouthwash vs Salt and soda mouthwash

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Chlorhexidine mouthwash showed no clear difference in time to heal mucositis (days) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Interventions for treating oral mucositis for patients with cancer receiving treatment 2010 · Cochrane All outcomes
MD -0.40 [-1.49, 0.69]
1 study · 100 participants
GRADE not reported

Chlorhexidine mouthwash vs Salt and soda mouthwash

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Chlorhexidine mouthwash showed no clear difference in average pain scores (0-100 VAS) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Interventions for treating oral mucositis for patients with cancer receiving treatment 2010 · Cochrane All outcomes
MD -3.50 [-13.35, 6.35]
1 study · 63 participants
GRADE not reported