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Evidence found and GRADE certainty

63 questions · 63 findings · 1 reviews

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No studies found 17 · 27%GRADE not reported 0 · 0%Very low 6 · 9.5%Low 18 · 28.6%Moderate 20 · 31.7%High 2 · 3.2%

Chloral hydrate oral (50 mg/kg) vs melatonin oral

Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse events (any) compared with melatonin oral (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs clonidine oral (4 μg/kg)

Number of children with clinical adverse event: drowsiness · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) probably leads to lower number of children with clinical adverse event: drowsiness compared with clonidine oral (4 μg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs clonidine oral (4 μg/kg)

Number of children with clinical adverse event: vertigo · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: vertigo compared with clonidine oral (4 μg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (60 mg/kg) vs music therapy

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (60 mg/kg) changes proportion of children who had sedation failure or inadequate level… compared with music therapy (very low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Bradycardia · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) leads to lower number of children with clinical adverse event: bradycardia compared with dexmedetomidine intranasal (3 μg/kg) (high certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Number of children with clinical adverse event: unsteadiness within 24 h after discharge · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: unsteadiness within… compared with dexmedetomidine intranasal (3 μg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Number of children with clinical adverse event: crying during administration of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) probably leads to higher number of children with clinical adverse event: crying during… compared with dexmedetomidine intranasal (3 μg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Vomiting · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: vomiting compared with dexmedetomidine intranasal (3 μg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who successfully completed neurodiagnostic procedure without interruption by the child awakening · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who required a further dose of either the same sedative agent or the addition of a different sedative agent · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review