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Evidence found and GRADE certainty

28 questions · 28 findings · 1 reviews

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No studies found 2 · 7.1%GRADE not reported 0 · 0%Very low 4 · 14.3%Low 8 · 28.6%Moderate 14 · 50%High 0 · 0%

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

Proportion of children with inadequate level of sedation (Ramsay score below 4) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) probably leads to lower proportion of children with inadequate level of sedation (Ramsay… compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

Proportion of children who had sedation failure after 1 dose of sedative agent · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) showed no clear difference in proportion of children who had sedation failure after 1 dose of… compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg or 100 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with dexmedetomidine oral (2 µg/kg or 3 µg/kg) (moderate certainty).

1 finding from 1 review