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Evidence found and GRADE certainty

383 questions · 397 findings · 37 reviews

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No studies found 59 · 14.9%GRADE not reported 11 · 2.8%Very low 70 · 17.6%Low 86 · 21.7%Moderate 110 · 27.7%High 61 · 15.4%

Summary of findings 1: PLD with chemotherapy vs alternative combination chemotherapy

Adverse events (grade ≥ 3) · platinum‐sensitive recurrent EOC

Summary of findings 1: PLD with chemotherapy showed no clear difference in overall severe adverse events (grade ≥ 3) compared with alternative combination chemotherapy (moderate certainty).

1 finding from 1 review

Summary of findings 1: PLD with chemotherapy vs alternative combination chemotherapy

Hand‐foot syndrome (grade ≥ 3) · platinum‐sensitive recurrent EOC

It is very uncertain whether summary of findings 1: PLD with chemotherapy changes hand‐foot syndrome (grade ≥ 3) compared with alternative combination chemotherapy (very low certainty).

1 finding from 1 review

Summary of findings 1: PLD with chemotherapy vs alternative combination chemotherapy

Neurological (grade ≥ 3) · platinum‐sensitive recurrent EOC

It is very uncertain whether summary of findings 1: PLD with chemotherapy changes neurological (grade ≥ 3) compared with alternative combination chemotherapy (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 2): second‐line chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with esophageal and GE‐junction carcinoma previously treated with chemotherapy

Summary of findings table (subcomparison 2): second‐line… probably leads to lower overall survival compared with control intervention alone (moderate certainty).

1 finding from 1 review

Summary of findings table (subcomparison 2): second‐line chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with esophageal and GE‐junction carcinoma previously treated with chemotherapy

Summary of findings table (subcomparison 2): second‐line… may leads to lower progression‐free survival compared with control intervention alone (low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 2): second‐line chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with esophageal and GE‐junction carcinoma previously treated with chemotherapy

It is very uncertain whether summary of findings table (subcomparison 2): second‐line… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review