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Evidence found and GRADE certainty

383 questions · 397 findings · 37 reviews

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No studies found 59 · 14.9%GRADE not reported 11 · 2.8%Very low 70 · 17.6%Low 86 · 21.7%Moderate 110 · 27.7%High 61 · 15.4%

Hysterectomy (simple or radical) with neoadjuvant chemotherapy vs Radiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with neoadjuvant chemotherapy probably leads to lower overall survival Median compared with radiotherapy alone (moderate certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with neoadjuvant chemotherapy vs Radiotherapy alone

Disease or progression‐free survival Median · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with neoadjuvant chemotherapy showed no clear difference in disease‐ or progression‐free survival Median compared with radiotherapy alone (moderate certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with neoadjuvant chemotherapy vs Radiotherapy alone

Severe adverse events and toxicity · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with neoadjuvant chemotherapy showed no clear difference in severe adverse events and toxicity compared with radiotherapy alone (low certainty).

1 finding from 1 review

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Progression‐free survival · people with advanced gastric cancer

Summary of findings: Molecular‐targeted therapy plus chemotherapy showed no clear difference in progression‐free survival compared with chemotherapy alone (low certainty).

1 finding from 1 review

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Overall response rate Duration of · people with advanced gastric cancer

Summary of findings: Molecular‐targeted therapy plus chemotherapy showed no clear difference in overall response rate Duration of compared with chemotherapy alone (low certainty).

1 finding from 1 review

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Adverse event (any) Duration of · people with advanced gastric cancer

Summary of findings: Molecular‐targeted therapy plus chemotherapy probably leads to higher adverse event (any) Duration of compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Severe adverse event (grade ≥ 3 ) Duration of · people with advanced gastric cancer

Summary of findings: Molecular‐targeted therapy plus chemotherapy probably leads to higher severe adverse event (grade ≥ 3 ) Duration of compared with chemotherapy alone (moderate certainty).

1 finding from 1 review